Mission District Vacations from $460
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Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
The Grove Inn
Western Addition
$685
per person
Oct 8 - Oct 13
found 1 day ago
Roundtrip flight included
Dallas (DFW) to San Francisco (SFO)
9.2/10 Wonderful! (729 reviews)
Wow! We thoroughly enjoyed our stay at The Grove! The location was absolutely perfect. Very walkable and public transit near the hotel takes you to many main attractions. The location is convenient. The neighborhood is charming. The hotel is authentic to San Francisco. And the rooms were pristine clean. We actually live - hour away but decided to do a short day trip, and staying here and the surrounding areas gave us a totally different view of San Francisco (in the best way possible!).
There are delicious and enjoyable shops, restaurants, coffee shops, and activities nearby including Fillmore Jazz Distric and Japantown (among others). There are a handful of beautiful parks with stunning views only a short distance away.
Street parking is available, but can be tough to find and has restrictions during the week (but we are familiar with SF so were prepared).
The rooms were very clean and the hotel was quiet and quaint. If I ever come back for a stay, I will hands down stay here again.
Reviewed on Aug 23, 2026
The Huntington Hotel
Downtown San Francisco
$814
per person
Oct 23 - Oct 26
found 9 hours ago
Roundtrip flight included
Los Angeles (LAX) to San Francisco (SFO)
9.6/10 Exceptional! (31 reviews)
Beautifully renovated and perfectly quiet. Would definitely stay here again!
Reviewed on Aug 13, 2026
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Fisherman's Wharf
1 out of top 10 points of interest in this area
Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.
Union Square
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
Downtown San Francisco
3 out of top 10 points of interest in this area
Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.
South of Market
From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.
Nob Hill
Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.
Mission District Hotel Deals
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
$149 nightly
$175 total
Sep 7 - Sep 8
Total with taxes and fees
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$167 nightly
$196 total
Aug 31 - Sep 1
Total with taxes and fees
Handlery Union Square Hotel
351 Geary St San Francisco CA
Fully refundableReserve now, pay when you stay
$160 nightly
$189 total
Sep 18 - Sep 19
Total with taxes and fees
8.8/10 Excellent! (3,467 reviews)
"Beds were very confortable and room was clean."
Reviewed on Aug 23, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Mission District attractions
Mission Dolores Park
9.4/10 (3 reviews)
Great views of downtown San Francisco, tree-shaded lawns and a children’s playground await at this popular hillside park in the vibrant Mission District.
Photo by Donny Campos
Mission San Francisco de Asís
Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the notable monuments and shops in this vibrant area.
Balmy Alley
Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene and fascinating museums in this vibrant area.
Southern Exposure
You can spend time studying the exhibits at Southern Exposure during your travels in San Francisco. Take in the acclaimed theater scene and beautiful sunsets in this vibrant area.
San Francisco Public Library
After visiting San Francisco Public Library, make a plan to see the other sights and activities in San Francisco. Discover the entertainment choices and notable monuments in this vibrant area.
SF Armory
You can learn about the history of San Francisco when you stop by SF Armory. Experience the acclaimed art scene and fascinating museums in this vibrant area.
Brick & Mortar Music Hall
You can enjoy a show at Brick & Mortar Music Hall during your trip to San Francisco. You can enjoy the bars while in the area.
The Great Northern
After visiting The Great Northern, make a plan to see the other sights and activities in San Francisco. You can enjoy the bars while in the area.
Things to do
Alcatraz Inside Prison Tour with Free App Audio Packages
$86
per adult
98% of travellers recommend
California Academy of Sciences Daytime Admission
$55
per adult
86% of travellers recommend
California Sunset Cruise (2-hours)
$58
per adult
94% of travellers recommend
Explore a world of travel with Expedia
- Old St. Mary's Cathedral
- Golden Gate Theatre
- Kezar Stadium
- Golden Gate Park
- San Francisco Zoo
- Painted Ladies
- Fouladi Projects
- Dragon's Gate
- Van Ness Avenue
- San Francisco Public Library
- Saints Peter and Paul Church
- De Young Museum
- Fisherman's Wharf Vacations
- Balmy Alley
- Crissy Field
- Lombard Street
- Mrs. Doubtfire House
- Telephone Pioneers Communication Museum
- San Francisco Museum of Modern Art
- St. Patrick Catholic Church
- Mission Creek Park
- Grace Cathedral
- Civic Center Vacations
- Civic Center Plaza
- Mission San Francisco de Asís
- Mission Dolores Park
- Embarcadero Center
- San Francisco African American Historical and Cultural Society
- Transamerica Pyramid
- Musée Mécanique
- The Fillmore
- Greek Theater
- Lotta's Fountain
- Orpheum Theatre
- Sf Masonic Auditorium
- Ghirardelli Chocolate Experience
- Westfield San Francisco Centre
- Twin Peaks
- San Francisco Vacations
- Golden Gate Bridge
- Pier 39
- Shn Curran Theatre
- San Francisco City Hall
- Yerba Buena Gardens
- Chase Center
- Sutro Tower
- San Francisco Botanical Garden
- Palace Hotel
- Westin St Francis Hotel Glass Elevators
- United Nations Plaza
- Sf Armory
- Yerba Buena Center for the Arts
- South Beach Vacations
- Bill Graham Civic Auditorium
- Haight-Ashbury Vacations
- Yerba Buena Ice Skating Center
- 450 Sutter Building
- San Francisco Federal Building
- Magowan's Infinite Mirror Maze
- Columbus Tower
- California Academy of Sciences
- Cathedral of Saint Mary of the Assumption
- 555 California Street
- Uss Pampanito
- 22nd St Hill
- Children's Creativity Museum
- Clarion Alley
- Maiden Lane
- Anchor Brewing Company
- Moscone Convention Center
- Walter S. Johnson Park
- Asian Art Museum of San Francisco
- Conservatory of Flowers
- American Conservatory Theater
- Museum of Craft and Folk Art
- Ucsf Medical Center at Mount Zion
- Morrison Planetarium
- Ghirardelli Square
- Muir Woods National Monument
- Aquarium of the Bay
- Alamo Square
- Ripley's Believe It Or Not Museum
- Grateful Dead House
- Palace of Fine Arts
- Academy of Art University
- The Regency Ballroom
- San Francisco Zen Center
- San Francisco Maritime National Historical Park
- Full House House
- Union Square Vacations
- Walt Disney Family Museum
- Japanese Tea Garden
- San Francisco Mint
- Pacific-Union Club
- Baker Beach
- St. Mary Square
- Alcatraz Island
- Coit Tower
- Warfield Theatre
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.