Mission District Vacations from $427
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Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Where to stay in Mission District
Union Square
Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
Fisherman's Wharf
Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.
Downtown San Francisco
Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.
South of Market
From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.
Nob Hill
Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.
Mission District Hotel Deals
Holiday Inn Golden Gateway by IHG
"everything was perfect staff, view and cleanliness."
Reviewed on Oct 9, 2026
Hotel Riu Plaza Fisherman's Wharf
"We did not like paying for a resort fee for not using the pool or gym. You should connect the room card to those amenities so only the people who use those things get charged. We did love the fireplaces outside to enjoy a book being read or enjoying a glass of wine. There does need to be security ..."
Reviewed on Oct 9, 2026
Hilton San Francisco Financial District
Stay near popular Mission District attractions
Mission Dolores Park
Mission San Francisco de Asís
Balmy Alley
San Francisco Public Library
Southern Exposure
SF Armory
Victoria Theatre
The Great Northern
Things to do
Alcatraz Inside tour with Round trip ferry & Audio App Packages
California Academy of Sciences Daytime Admission
California Sunset Cruise (2-hours)
Explore a world of travel with Expedia
- Old St. Mary's Cathedral
- Golden Gate Theatre
- Kezar Stadium
- Golden Gate Park
- San Francisco Zoo
- Painted Ladies
- Fouladi Projects
- Dragon's Gate
- Van Ness Avenue
- San Francisco Public Library
- Saints Peter and Paul Church
- De Young Museum
- Fisherman's Wharf Vacations
- Balmy Alley
- Crissy Field
- Lombard Street
- Mrs. Doubtfire House
- Telephone Pioneers Communication Museum
- San Francisco Museum of Modern Art
- St. Patrick Catholic Church
- Mission Creek Park
- Grace Cathedral
- Civic Center Vacations
- Civic Center Plaza
- Mission San Francisco de Asís
- Mission Dolores Park
- Embarcadero Center
- San Francisco African American Historical and Cultural Society
- Transamerica Pyramid
- Musée Mécanique
- The Fillmore
- Greek Theater
- Lotta's Fountain
- Orpheum Theatre
- Sf Masonic Auditorium
- Ghirardelli Chocolate Experience
- Westfield San Francisco Centre
- Twin Peaks
- San Francisco Vacations
- Golden Gate Bridge
- Pier 39
- Shn Curran Theatre
- San Francisco City Hall
- Yerba Buena Gardens
- Chase Center
- Sutro Tower
- San Francisco Botanical Garden
- Palace Hotel
- Westin St Francis Hotel Glass Elevators
- United Nations Plaza
- Sf Armory
- Yerba Buena Center for the Arts
- South Beach Vacations
- Bill Graham Civic Auditorium
- Haight-Ashbury Vacations
- Yerba Buena Ice Skating Center
- 450 Sutter Building
- San Francisco Federal Building
- Magowan's Infinite Mirror Maze
- Columbus Tower
- California Academy of Sciences
- Cathedral of Saint Mary of the Assumption
- 555 California Street
- Uss Pampanito
- 22nd St Hill
- Children's Creativity Museum
- Clarion Alley
- Maiden Lane
- Anchor Brewing Company
- Moscone Convention Center
- Walter S. Johnson Park
- Asian Art Museum of San Francisco
- Conservatory of Flowers
- American Conservatory Theater
- Museum of Craft and Folk Art
- Ucsf Medical Center at Mount Zion
- Morrison Planetarium
- Ghirardelli Square
- Muir Woods National Monument
- Aquarium of the Bay
- Alamo Square
- Ripley's Believe It Or Not Museum
- Grateful Dead House
- Palace of Fine Arts
- Academy of Art University
- The Regency Ballroom
- San Francisco Zen Center
- San Francisco Maritime National Historical Park
- Full House House
- Union Square Vacations
- Walt Disney Family Museum
- Japanese Tea Garden
- San Francisco Mint
- Pacific-Union Club
- Baker Beach
- St. Mary Square
- Alcatraz Island
- Coit Tower
- Warfield Theatre