Mission District Vacations from $532
Book a Hotel + Flight or Car together to unlock savings
Your Mission District Vacation
Experience all the wonderful things this neighborhood has to offer with a tailor-made Mission District vacation package. However you picture yourself spending your days here, you'll find countless opportunities for fun, relaxation and adventure. Can't wait to get out and see the sights during your trip to Mission District? Be sure to check out nearby attractions like Lombard Street, University of San Francisco and University of California, San Francisco. Expedia is here to put your plans into action. Book your perfect Mission District vacation now.
The Latest Mission District Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Motel 6 San Francisco, CA – Great Highway
Golden Gate
Save 100% on your flight
Price was $860, price is now $532 per person
$532
per person
Aug 4 - Aug 8
found 20 hours ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
6.8/10 (621 reviews)
No ac and only heat and the fridge wasn’t working. Over all just to sleep it was ok..
Reviewed on Jun 11, 2026
The Westin St. Francis San Francisco on Union Square
Union Square
Price was $1,555, price is now $623 per person
$623
per person
Aug 27 - Aug 31
found 1 day ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
8.8/10 Excellent! (2,357 reviews)
I love staying at the St. Francis. It’s my hotel of choice every time I visit San Francisco.
The hotel is great, the staff professional, friendly and personable.
Reviewed on Jun 12, 2026
Hotel Riu Plaza Fisherman's Wharf
Fisherman's Wharf
Save 100% on your flight
Price was $1,242, price is now $719 per person
$719
per person
Aug 4 - Aug 8
found 20 hours ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9/10 Wonderful! (7,567 reviews)
Great location and good breakfast
Reviewed on Jun 15, 2026
Beacon Grand, A Union Square Hotel
Union Square
Save 100% on your flight
Price was $1,001, price is now $603 per person
$603
per person
Aug 4 - Aug 8
found 20 hours ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9.2/10 Wonderful! (2,076 reviews)
Beautiful historical hotel near everything you would need or want when visiting San Francisco.
Reviewed on Jun 14, 2026
The Jay, Autograph Collection
Downtown San Francisco
Save 100% on your flight
Price was $1,443, price is now $877 per person
$877
per person
Aug 4 - Aug 8
found 20 hours ago
Roundtrip flight included
Burbank (BUR) to San Francisco (SFO)
9.4/10 Exceptional! (420 reviews)
Everything was perfect and beautiful. Food quality and service was outstanding
Reviewed on Jun 15, 2026
Where to stay in Mission District
Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Fisherman's Wharf
1 out of top 10 points of interest in this area
4/5(39 area reviews)
Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.
Mission District Hotel Deals
Hotel Riu Plaza Fisherman's Wharf
2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
$176 nightly
The price is $207 total per night from Jul 5 to Jul 6
$207 total
Jul 5 - Jul 6
Total with taxes and fees
9/10 Wonderful! (7,605 reviews)
"Great location and good breakfast"
Reviewed on Jun 15, 2026
Holiday Inn Golden Gateway by IHG
1500 Van Ness Ave San Francisco CA
$140 nightly
The price is $165 total per night from Jul 5 to Jul 6
$165 total
Jul 5 - Jul 6
Total with taxes and fees
9/10 Wonderful! (5,866 reviews)
"Rooms were really clean, great staff, great places nearby"
Reviewed on Jun 15, 2026
Hilton San Francisco Union Square
333 O'Farrell St. San Francisco CA
Fully refundableReserve now, pay when you stay
$147 nightly
The price is $173 total per night from Jul 3 to Jul 4
$173 total
Jul 3 - Jul 4
Total with taxes and fees
8.6/10 Excellent! (1,378 reviews)
"Good location and parking was easy and at a reasonable price."
Reviewed on Jun 15, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Mission District attractions
Explore a world of travel with Expedia
- San Francisco Hotels
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- Hotels near Downtown San Francisco
- Hotels near Hua Zang Si
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- Hotels near Clarion Alley
- Hotels near Women's Building
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- Motels in 16th Street Mission Station
- Hotels near San Francisco Public Library
- Hotels near 24th Street Mission Station
- Hotels near Ratio 3
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- Hotels near Mission High School
- Hotels near Mission Dolores
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- Hotels near Hosfelt Gallery
- Hotels near Galería de la Raza
- Hotels near 22nd St Hill
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- Vacation Homes in Church St & 24th St Stop
- Hotels near Market St & Dolores St Stop
- Hotels near Anchor Brewing Company
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- Hotels near Church Street Station
- Hotels near Market St & Buchanan St Stop
- Hotels near Market St & Guerrero St Stop
- Hotels near Market St & Laguna St Stop
- B&B in Church St & 14th St Stop
- Hotels near Market St & Sanchez St Stop
- Hotels near SOMArts
- Hotels near Church St & Clipper St Stop
- Hotels near U.S. Mint
- Hotels near Duboce Ave & Church St Stop
- Hotels near Emergence Healing Arts Studio
- Hotels near Bill Graham Civic Auditorium
- Gay friendly Hotels in Castro District
- Hotels near Castro Street
- San Francisco Vacations
- Hua Zang Si
- Marsh Theater
- Mission Dolores Park
- Sf Armory
- Mission San Francisco de Asís
- Galería de la Raza
- Castro Street
- 22nd St Hill
- Visit Downtown San Francisco
- Fouladi Projects
- San Francisco City Hall
- U.s. Mint
- Visit Mission Dolores
- Castro Theatre
- Harvey Milk Plaza
- San Francisco Zen Center
- Louise Davies Symphony Hall
- Noe Valley Vacations
- The Promenade
- Bill Graham Civic Auditorium
- Randall Museum
- Nobby Clarke Mansion
- Visit Castro District
- Randall Museum
- Golden Gate Model Railroad Club
- Mission Creek Park
- Corona Heights Park
- War Memorial Opera House
- Orpheum Theatre
- Civic Center Plaza
- Vulcan Steps
- Mclellan Botanicals
- Painted Ladies
- San Francisco Federal Building
- Kite Hill Open Space
- Asian Art Museum of San Francisco
- United Nations Plaza
- California State Building
- Alamo Square
- Haight Street
- Chase Center
- Van Ness Avenue
- Visit Bernal Heights
- Twin Peaks
- Academy of Art University
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.